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(A, B, C) Curves representing ellipticity across the far UV spectra of CCHFV NP (A), Affimer-NP (B) or a 1:1 mixture of both (C) at 20ºC-90ºC. Crystal structure of Affimer scaffold (PDB:4n6u) is represented in orange and CCHFV NP (PDB:4akl) in blue. (D, E, F) Curves representing folded/unfolded fractions and melting temperatures (Tm) of Affimer-NP (D), CCHFV NP (E) and their mixture (F).
