Table 2.
Weight | 3TC + DTG | RPV + DTG | PI + DTG | 3TC/ABC/DTG | TDF/FTC + DTG | TAF/FTC + DTG | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
No. | Mean | No. | Mean | No. | Mean | No. | Mean | No. | Mean | No. | Mean | |
T1-T0 | 75 | –0.1 ± 0.4 | 45 | 0.8 ± 0.3a | 60 | 1.2 ± 0.3a | 326 | 0.1 ± 0.2 | 148 | 1.5 ± 0.3a | 59 | 1.3 ± 0.5a |
T2-T1 | 44 | 1.0 ± 0.4a | 34 | 0.6 ± 0.6 | 51 | 0.1 ± 0.3 | 250 | 0.1 ± 0.2 | 137 | 1.0 ± 0.4a | 14 | 1.6 ± 0.4a |
T3-T2 | 28 | –0.7 ± 0.2a | 30 | 0.4 ± 0.3 | 40 | –0.2 ± 0.3 | 191 | –0.3 ± 0.2 | 115 | 0.3 ± 0.5 | 3 | –1.0 ± 0.6 |
T4-T3 | 24 | –0.3 ± 1.0 | 27 | –0.2 ± 0.4 | 36 | 0.3 ± 0.5 | 150 | 0.5 ± 0.3 | 92 | 0.5 ± 0.3 | 1 | – |
T0 = baseline; T1 = 6 months; T2 = 12 months; T3 = 18 months; T4 = 24 months.
Abbreviations: 3TC, lamivudine; ABC, abacavir; DTG, dolutegravir; FTC, emtricitabine; RPV, rilpivirine; PI, protease inhibitor (atazanavir, darunavir); TAF, tenofovir alafenamide; TDF, tenofovir disoproxil fumarate.
a P < .05 for change from baseline (T1-T0) or previous follow-up visit (T2-T1, T3-T2, T4-T3).