Figure 2.

BCG Does Not Alter the Composition of Immune Cells and Progenitors in Blood and BM

(A) Whole blood counts of neutrophils, lymphocytes, and monocytes as fold change relative to D0.

(B and D) Uniform manifold approximation and projection (UMAP) representation of analyzed cell lineages of the alive Lin (CD3, CD7, CD10, CD15, CD19, and CD20)⁻ CD45⁺ compartment in PBMC (B) and Lin (CD3, CD7, CD15, CD19, and CD20)⁻ CD45⁺ BM MNC (D) (representative donor, 5 × 10⁵ sampled cells).

(C and E) Quantification of cell types depicted in (B) and (D) as proportion of Lin⁻CD45⁺ relative to D0 for all time points (mean and SD; D0/D90, BCG, n = 15, Ctrl, n = 5; D14, BCG, n = 7, Ctrl, n = 2).

Unpaired t test was used in (A), (C), and (E) to compare BCG versus Ctrl D90 (all p values > 0.05). See also Figure S1.