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. 2020 Jun 11;13:5443–5453. doi: 10.2147/OTT.S250066

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© 2020 Zhang et al.

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Identification of PSAT1 as a novel biomarker in EOC tissues. (A) The pathway relation network indicated that vitamin B6 metabolism was associated with EOC tumorigenesis. (B) Gene signal network indicated that key enzymes in the serine-glycine synthesis pathway were associated with EOC tumorigenesis. (C) PSAT1 mRNA levels (Oncomine) in (a) normal ovary versus ovarian serous cystadenocarcinoma (TCGA data), (b) normal lung versus lung adenocarcinoma (Okayama Lung data), (c) normal colon versus colorectal carcinoma (Hong Colorectal data). (D) The mRNA levels of PHGDH, PSPH, SHMT1, SHMT2, MTHFD1, and MTHFD2 (Oncomine) were analyzed in normal ovary versus ovarian serous cystadenocarcinoma.