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. Author manuscript; available in PMC: 2020 Jun 15.
Published in final edited form as: Biochim Biophys Acta Mol Basis Dis. 2018 Sep 1;1865(7):1718–1744. doi: 10.1016/j.bbadis.2018.08.039

Fig. 6.

Fig. 6.

The changes in chromatin states with aging. Increased cellular senescence results in a loss of heterochromatin caused by the factors depicted in the diagram. (From Booth and Brunet [256])