Table 1. Baseline clinical and ophthalmologic characteristics of subjects according to response at immediate and 3 months after steroid treatment.
| Characteristics | Immediate after steroid treatment | Three months after steroid treatment | ||||
|---|---|---|---|---|---|---|
| Non-responsive group (n = 30) | Responsive group (n = 24) | P value | Non-responsive group (n = 32) | Responsive group (n = 22) | P value | |
| Age, yr | 48.5 ± 12.3 | 44.6 ± 12.8 | 0.263 | 49.9 ± 11.6 | 42.1 ± 12.8 | 0.023 |
| Gender, men | 7 (23.3) | 11 (45.8) | 0.081 | 10 (31.3) | 8 (36.4) | 0.695 |
| Body mass index, kg/m2 | 22.7 ± 2.4 | 22.8 ± 2.7 | 0.889 | 22.67 ± 2.24 | 22.92 ± 2.95 | 0.732 |
| Duration of GO, mon | 14.6 ± 18.6 | 13.5 ± 14.9 | 0.808 | 15.1 ± 19.4 | 12.7 ± 12.8 | 0.616 |
| Thyroid hormone medication | 3 (10.0) | 1 (4.2) | 0.416 | 4 (12.5) | 0 (0.0) | 0.085 |
| Never smoker | 20 (66.7) | 13 (54.2) | 0.349 | 21 (65.6) | 12 (54.5) | 0.412 |
| Sum of EOM, mm | 21.11 ± 4.81 | 21.03 ± 4.45 | 0.952 | 20.91 ± 4.57 | 21.32 ± 4.77 | 0.755 |
| TSH, µIU/mL | 2.17 ± 4.11 | 1.38 ± 2.48 | 0.426 | 1.94 ± 4.02 | 1.62 ± 2.54 | 0.748 |
| Free T4, ng/dL | 1.36 ± 0.83 | 1.32 ± 0.58 | 0.873 | 1.38 ± 0.81 | 1.28 ± 0.58 | 0.635 |
| Initial TBII, IU/L | 21.74 ± 15.65 | 11.81 ± 9.84 | 0.008 | 20.80 ± 15.44 | 12.20 ± 10.40 | 0.021 |
| Total cholesterol, mg/dL | 200.9 ± 39.0 | 192.5 ± 46.4 | 0.485 | 202.1 ± 41.6 | 190.2 ± 42.8 | 0.325 |
| MRD1, mm | 3.94 ± 1.51 | 3.79 ± 1.54 | 0.725 | 3.73 ± 1.65 | 4.08 ± 1.28 | 0.411 |
| Palpebral fissure, mm | 9.56 ± 1.90 | 9.14 ± 2.48 | 0.490 | 9.08 ± 2.20 | 9.79 ± 2.09 | 0.240 |
| Proptosis, mm | 19.03 ± 2.99 | 18.50 ± 3.13 | 0.527 | 18.33 ± 2.84 | 19.48 ± 3.26 | 0.175 |
| Any diplopia | 14 (46.7) | 13 (54.2) | 0.584 | 15 (46.9) | 12 (54.5) | 0.580 |
| NOSPECS class II, minimal/moderate/marked, % | 23.3/66.7/10.0 | 0.0/95.8/4.2 | 0.022 | 18.8/71.9/9.4 | 4.5/90.9/4.5 | 0.219 |
| CAS, 3/ ≥ 4, % | 53.3/46.7 | 37.5/62.5 | 0.246 | 53.1/46.9 | 36.4/63.6 | 0.225 |
Data are presented as mean ± standard deviation or number (%).
GO = Graves' ophthalmopathy, EOM = extraocular muscle, TSH = thyroid stimulating hormone, TBII = thyrotropin binding inhibitory immunoglobulin, MRD = margin reflex distance, CAS = clinical activity score.