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. Author manuscript; available in PMC: 2021 Feb 25.
Published in final edited form as: ACS Nano. 2020 Feb 7;14(2):2324–2335. doi: 10.1021/acsnano.9b09498

Figure 2.

Figure 2.

Characterization of extended and fluorescently labeled microRNA at the single molecule level. (a) Fluorescence micrographs of Cy3-conjugated dye-DNA probes (left) and miR-375 amplicons labeled with the same dye-DNA probes (right). Scale bars represent 5 μm. Intensity histograms are shown below for probes alone (blue) and labeled microRNA products (red). (b) Temporal fluorescence intensity in a diffraction limited confocal spot for dye-DNA probes in solution (top) and labeled microRNA products (bottom).