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. 2020 Jun 15;40(6):BSR20200466. doi: 10.1042/BSR20200466

Figure 5. miR-137 protected chondrocytes by inhibiting AMPK/NF-κB pathway and apoptosis.

Figure 5

(A) Up-regulation of miR-137 or down-regulation of TCF4 can weaken the regulation of LPS on AMPK/NF-κB pathway. (B) AMPK/NF-κB pathway related protein map. (C) Up-regulation of miR-137 or down-regulation of TCF4 can inhibit the higher apoptosis rate of chondrocytes caused by LPS. (D) Flow cytometry. Note: Compared with the control group, *P<0.05, **P<0.01; Compared with LPS group, #P<0.05. Abbreviations: AMPK, AMP-activated protein kinase; C, Compound C; FITC, fluorescein isothiocyanate; IκB-α, inhibitor of nuclear factor kappaB-α; LPS, lipopolysaccharide; miR, microRNA; NF-κB, nuclear factor-kappa B; p, phosphorylation; p65, transcription factor p65; si, short interfering; TCF4, transcription factor 4.