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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Ann Plast Surg. 2020 Oct;85(4):424–429. doi: 10.1097/SAP.0000000000002110

Figure 4:

Figure 4:

4a. Fibroblast Cell Death. Healthy fibroblast cells pre-treated with WR-1065 demonstrated a significant reduction in cell death compared to untreated controls at 10 Gy (14.5% vs. 39.3%, p<0.001). WR-1065 pre-treatment also preserved healthy FF cell viability compared to untreated controls at 20 Gy (19.4% vs. 52.7%, p=0.008). 4b. Fibroblast Microscopic Images. Untreated fibroblasts at 10 Gy show decreased cell density compared to untreated controls at 0 Gy. There is even further reduction in cell density for untreated FF cells at 20 Gy. FF cells pre-treated with WR-1065, however, demonstrate marked preservation of FF cell density. There is marked retention in cells compared to untreated FF at both 10 Gy and 20 Gy. WR-1065 pre-treatment preserves FF cell density, to levels similar to non-irradiated (0 Gy) controls.