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. 2020 Jun 15;10:9637. doi: 10.1038/s41598-020-66062-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Screening cohort tumor microRNA expression a) and b). Expression levels in tumor of relevant microRNAs are plotted as intensity (median, 25% and 75% percentiles). Array data were normalized using robust multi-array average. Up-regulated c) and Down-regulated d) plasma microRNAs plotted as fold change (2^−ΔΔCt) difference between cases and controls (median, 25% and 75% percentiles). RT-PCR data were normalized using miR-23a. Statistically significant difference (<0.0003) between cases and controls adjusted for age and sex in quantile regressions is marked with a *.