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. 2020 Jun 15;6:51. doi: 10.1038/s41420-020-0286-z

Fig. 2. Signaling cross talks in senescence and EMT.

Fig. 2

Cells undergoing premature senescence have elevated ROS levels resulting in the induction of p21 and other cell cycle check point kinases. Various CDKIs repress the EMT-associated transcription factors like Twist-1, Zeb1 and Snail1. On the contrary, cells in EMT have diminished p21/p27 and p14/p16 levels due to activated Twist-1 levels and other EMT-associated transcription factors.