Table 1.

Effectors of senescence.

S. No.	Effectors	Encoding gene	Interacting partners	Cyclins	Cell cycle arrest	Type of senescence	References
1	p14ARF (Ink4a)	CDKN2A	CDK4, CDK6	D	G1	OIS, TIS	24,35,79
2	p15 (Ink4b)	CDKN2B	CDK4	D	G1	RS, OIS	33,80
3	p16 (Ink4a)	CDKN2A	CDK4,CDK6	D	G1	OIS, RS, TIS	32,34,81
4	p18 (Ink4c)	CDKN2C	CDK4, CDK6	D	G1	RS, OIS	82
5	p19 (Ink4d)	CDKN2D	CDK4, CDK6	D	G1	OIS, TIS	16,35
6	p21 (Waf1, Cip1)	CDKN1A	CDK1, CDK2, CDK 4, CDK6	A, D, E	G1, G1/S	OIS, RS, SIPS, TIS	22,69,83
7	p27 (Kip1)	CDKN1B	CDK2, CDK4	D, E	G1, G1/S	OIS, SIPS, TIS	84,85
8	p57 (Kip2)	CDKN1C	CDK2, CDK3	E	G1, G1/S	SIPS, TIS	86,87

CDK cyclin dependent kinase, OIS oncogene-induced senescence, RS replicative senescence, SIPS stress induced premature senescence, TIS therapy-induced senescence.