Table 3.
EMPHASIS cohort. Association between LTL (T/S mean z-score) and seasonality.
| N | LRT χ2 (2 df) | LRT p-value | |
|---|---|---|---|
| Model 1 – crude seasonality modelled with one pair of Fourier termsa Baseline: intercept only | 218 | 8.27 | 0.016 |
| Model 2 – adjusted for age and sex 1 pair Fourier terms + age + sex Baseline: age and sex only | 218 | 7.89 | 0.019 |
| Model 3 – adjusted for age, sex and estimated white cell composition 1 pair Fourier terms + age + sex + cell composition Baseline: age + sex + cell composition only | 214 | 7.10 | 0.029 |
| Model 4 – adjusted for age, sex and maternal BMI 1 pair Fourier terms + age + sex + maternal BMI Baseline: age + sex + maternal BMI only | 218 | 7.96 | 0.019 |
| Model 5 – adjusted for age + sex + birthweight 1 pair Fourier terms + age + sex + birthweight Baseline: age + sex + birthweight | 200 | 6.51 | 0.039 |
aIn each case, model fit is assessed by comparing the full and baseline models using a likelihood ratio test (LRT). LRT confirmed that two/three pairs of Fourier terms did not improve model fit. BMI, Body Mass Index.