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. 2020 Jun 15;11:3018. doi: 10.1038/s41467-020-16589-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Kaplan–Meier plots showing the survival of mice of the indicated genotypes in the Pdx1^Cre;Kras^G12D (left) and Ptf1α^Cre;Kras^G12D (right) cohorts. Median survival is shown in brackets. The Log-rank (Mantel–Cox) test was used to assess statistical significance between groups. n, number of mice. b H&E staining of 10–15-week-old pancreata from the Pdx1^Cre cohort lacking Bap1 with histological alterations resembling mucinous cystic neoplasms (MCNs) and intraductal papillary mucinous neoplasms (IPMNs). Asterisks indicate ovarian type stroma lined by mucin-producing cells in MCN and arrows point to the foveolar epithelium. c IHC for the indicated mucins in Pdx1^Cre;Kras^G12D;Bap1^KO tumors isolated from 10- to 15-week-old mice. Arrows point to areas of the foveolar epithelium. d Top: Oncoprint showing the overlap between heterozygous loss of BAP1 and mutations in the indicated oncogenes and tumor suppressors in the TCGA-PAAD cohort. Bottom: Table showing the percentage of patients with heterozygous loss of BAP1 and mutations in the indicated genes. ACC, acinar cell carcinoma. e H&E, Periodic Acid–Schiff staining with Diastase digestion (PAS-D) and IHC for ductal (Cytokeratin 17/19 and Sox9) and acinar (Amylase and Trypsin-2) markers in 25–30-week-old mice of the indicated genotypes. Arrows point to PAS-D-positive cytoplasmic staining of cells in areas with histological features resembling ACC. Source data are provided as a Source Data file.