Table 1.
Characteristics of included studies in this meta-analysis.
| References | Location | Sample size (n, male) | Mean/median age | COVID-19 severity | Extracted indicators | Minors score | |
|---|---|---|---|---|---|---|---|
| Severe | Non-severe | ||||||
| Bin et al. (12) | Wuhan | 54 (30) | 53.9 | 9 | 45 | WBC; L | 18 |
| Cai et al. (23) | Shenzhen | 298 (145) | 47.5 | 58 | 240 | CRP; PCT; WBC; N; L; ESR; IL-6 | 21 |
| Chen et al. (33) | Wuhan | 150 (84) | 59 | 24 | 126 | CRP | 18 |
| Chen et al. (34) | Chongqing | 139 (76) | 46 | 31 | 108 | WBC; N; L; NLR | 18 |
| Chen et al. (35) | Guangzhou | 296 (137) | NA | 30 | 266 | WBC; N; L; NLR | 20 |
| Fang et al. (36) | Anhui | 79 (45) | 45.1 | 24 | 55 | CRP; WBC; N; L | 18 |
| Gao et al. (37) | Beijing | 90 (43) | 53 | 22 | 55 | CRP; PCT; WBC; L; ESR; IL-6 | 20 |
| Guan et al. (38) | national | 1,099 (637) | 47 | 173 | 926 | WBC; L | 18 |
| Hou et al. (39) | Chengdu | 56 (29) | 48 | 11 | 38 | L; CD3; CD4; CD8; NLR | 20 |
| Huang et al. (13) | Wuhan | 41 (30) | 49 | 13 | 28 | PCT; WBC; N; L | 21 |
| Li et al. (15) | Wuhan | 62 (32) | NA | 22 | 18 | CRP; PCT; WBC; N; L; CD3; CD4; CD8 | 19 |
| Li et al. (14) | Zhuzhou | 80 (40) | 47.8 | 17 | 63 | CRP; PCT; WBC; L; ESR | 20 |
| Li et al. (16) | Chongqing | 83 (44) | 45.5 | 25 | 58 | CRP; PCT; WBC; N; L; M | 18 |
| Li et al. (17) | Beijing | 46 (21) | 45.6 | 6 | 40 | CRP; PCT; WBC; N; L | 18 |
| Liu et al. (18) | Wuhan | 78 (39) | 38 | 11 | 67 | CRP; PCT; WBC; N; L; ESR | 18 |
| Long et al. (19) | Jingzhou/Xiangyang | 301 (150) | 51 | 36 | 245 | NLR | 18 |
| Lu et al. (20) | Wuhan | 101 (34) | NA | 34 | 67 | CRP; WBC; N; L; CD3; CD4; CD8 | 19 |
| Peng et al. (21) | Wuhan | 112 (53) | 62 | 16 | 96 | CRP; PCT; WBC; N; L; M; NLR | 19 |
| Qin et al. (8) | Wuhan | 452 (235) | 58 | 286 | 166 | CRP; PCT; WBC; N; L; M; CD3; CD4; CD8; ESR; IL-6; NLR | 20 |
| Wan et al. (22) | Chongqing | 153 (77) | NA | 21 | 132 | CRP; PCT; L; CD3; CD4; CD8 | 21 |
| Wan et al. (24) | Chongqing | 135 (72) | 47 | 40 | 95 | CRP; PCT; WBC; N; L | 19 |
| Wang et al. (25) | Wuhan | 138 (75) | 56 | 36 | 102 | WBC; N; L; M | 21 |
| Wu et al. (26) | Wuhan | 201 (128) | 51 | 84 | 117 | CRP; WBC; N; L; M; CD3; CD4; CD8; ESR; IL-6 | 19 |
| Xiang et al. (32) | Jiangxi | 49 (33) | 42.9 | 9 | 40 | CRP; PCT; WBC; N; L; CD3; CD4; CD8; ESR | 18 |
| Yang et al. (27) | Hangzhou | 93 (56) | 46.4 | 24 | 69 | CRP; WBC; N; L; M; NLR | 19 |
| Yuan et al. (28) | Chongqing | 223 (106) | 46.5 | 31 | 192 | PCT; WBC; L | 19 |
| Zhang et al. (29) | Wuhan | 138 (71) | 57 | 56 | 82 | CRP; PCT; WBC; L | 21 |
| Zhang et al. (30) | Beijing | 74 (35) | 52.7 | 9 | 56 | CRP; PCT; WBC; N; L | 20 |
| Zheng et al. (31) | Changsha | 161 (80) | 45 | 30 | 131 | CRP; WBC; L | 18 |
WBC, white blood cell; N, neutrophil; L, lymphocyte; M, monocyte; CD3, T cell; CD4, helper T cell; CD8, cytotoxic T cell; ESR, erythrocyte sedimentation rate; IL-6, Interleukin-6; NLR, neutrophil-lymphocyte ratio; CRP, C-reactive protein; PCT, procalcitonin; NA, not available.