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. 2020 Jun 9;11:1090. doi: 10.3389/fimmu.2020.01090

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Copyright © 2020 Binder, Cvetkovski, Sellberg, Berg, Paternina Visbal, Sachs, Berglund and Berglund.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic illustration of the immunological synapse and spatial distribution of TCR/MHC and costimulatory molecules. Illustration is for explanatory purposes and relative sizes of different molecules are not necessarily to scale. Regions include central supramolecular activation cluster (cSMAC), peripheral SMAC (pSMAC), CD2/LFA3 corolla and distal SMAC (dSMAC). CD2 (green) is positioned in the T cell plasma membrane (light red) and locates to both the cSMAC and corolla. CD2 binds to lymphocyte-associated antigen 3 (LFA3; dark blue) which is located in the plasma membrane of the antigen-presenting cell (light blue). Among other molecules, TCR/pMHC and CD28/CD80/86 complexes also locate to the cSMAC. LFA-1/ICAM-1 complexes predominantly locate to the pSMAC. See main text for references.