Table 1.
Quantitative measures of reference sphere in normal liver tissue for 68Ga-DOTATOC, 18F-fluoride, and 11C-acetate
| Measure | OSEM | BSREM | |||
|---|---|---|---|---|---|
| β 133 | β 267 | β 400 | β 533 | ||
| 68Ga-DOTATOC | |||||
| Volume mL | 18.5 (16.8–19.6) | ||||
| SUVmax | 8.7 (5.1–11.4) | 13.5 (9.6–20.1) | 9.9 (6.2–13.8) | 8.8 (5.1–12.0) | 8.3 (4.5–11.5) |
| SUVmean | 6.2 (3.0–8.0) | 6.2 (3.0–8.1) | 6.2 (3.0–8.1) | 6.2 (3.0–8.1) | 6.2 (3.0–8.1) |
| P* | > 0.7 | > 0.8 | > 0.9 | > 0.9 | |
| SUVSD | 0.8 (0.4–1.1) | 1.5 (0.8–2.0) | 1.0 (0.5–1.4) | 0.8 (0.4–1.1) | 0.7 (0.3–1.0) |
| Noise† | 0.13 (0.07–0.21) | 0.25 (0.14–0.44) | 0.16 (0.09–0.27) | 0.13 (0.08–0.21) | 0.12 (0.07–0.18) |
| 18F-Fluoride | |||||
| Volume mL | 18.5 (16.5–19.6) | ||||
| SUVmax | 1.0 (0.6–1.3) | 3.0 (1.4–6.7) | 1.7 (0.8–3.6) | 1.1 (0.6–1.5) | 0.9 (0.5–1.3) |
| SUVmean | 0.4 (0.3–0.7) | 0.4 (0.3–0.7) | 0.4 (0.3–0.7) | 0.4 (0.3–0.7) | 0.4 (0.3–0.7) |
| P* | > 0.7 | > 0.3 | > 0.2 | > 0.3 | |
| SUVSD | 0.1 (0.1–0.2) | 0.3 (0.2–0.5) | 0.2 (0.1–0.3) | 0.1 (0.1–0.2) | 0.1 (0.1–0.2) |
| Noise† | 0.30 (0.22–0.40) | 0.32 (0.22–0.49) | 0.31 (0.16–0.49) | 0.33 (0.23–0.49) | 0.30 (0.16–0.49) |
| 11C-Acetate | |||||
| Volume mL | 18.7 (18.0–19.6) | ||||
| SUVmax | 5.7 (2.5–11.2) | 6.3 (2.6–11.3) | 5.6 (2.3–10.7) | 5.3 (2.2–10.5) | 5.2 (2.2–10.3) |
| SUVmean | 4.3 (1.8–8.2) | 4.3 (1.8–8.1) | 4.3 (1.8–8.1) | 4.3 (1.8–8.1) | 4.3 (1.8–8.1) |
| P* | > 0.5 | > 0.1 | > 0.1 | > 0.05 | |
| SUVSD | 0.4 (0.2–1.0) | 0.5 (0.3–1.1) | 0.4 (0.2–0.9) | 0.3 (0.2–0.8) | 0.3 (0.1–0.8) |
| Noise† | 0.10 (0.07–0.14) | 0.13 (0.09–0.16) | 0.09 (0.07–0.12) | 0.08 (0.05–0.11) | 0.07 (0.05–0.11) |
†Noise was defined as SUVSD divided by SUVmean
*P: Wilcoxon’s signed rank test, for BSREM to OSEM on SUVmean
BSREM block-sequential regularized expectation maximization, OSEM ordered subsets expectation maximization, SUV standardized uptake value, SD standard deviation
Reconstruction methods were OSEM (3 iterations, 16 subsets, 5-mm Gaussian post-processing filter) and BSREM with β-values of 133, 267, 400, and 533, and 2 min/bp. Both reconstruction methods include TOF and PSF recovery. Values represent mean (range)