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. 2020 Jun 15;10:9645. doi: 10.1038/s41598-020-66393-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The performance of the sensor for detection of sensitivity and specificity using DPV measured at a scan rate 50 mV s-1 in phosphate buffer (pH = 7.4). (A) DPV of the cuco₂o4/p19/ SCPE/GNP sensor with 0.1 µl P19, obtained using (f) 100 fM, (e) 1 fM, (d) 500 aM, (c)100 aM, (b) 10 aM, (a)1 aM of miR21 in the incubation buffer. (B) A calibration plot of the current density vs log concentration of miR-21 in DOPC-AuNP. (C) DPV of the cuco2o4/p19/ SCPE/GNP sensor with 0.5 µl P19obtained using (a) (f) 100 fM, (e) 1 fM, (d) 500 aM, (c)100 aM, (b) 10 aM, (a)1 aM of miR21 in the incubation buffer. (D) A calibration plot of the current density vs log concentration of miR-21 in DOPC/AuNP. (E) Specify of cuco2o4/p19/ SCPE/GNP sensor for detection complementary 21miR.