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. 2020 Jun 15;11:3035. doi: 10.1038/s41467-020-15541-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a We hypothesized that the strength of the connection between the frontoparietal and default-mode systems can be tuned by altering the relative amplitudes of subnetworks within the frontoparietal system. b Community detection reveals two distinct frontoparietal subnetworks, which we show here projected onto the cortical surface. c We found that the activity of subnetwork (A) was positively correlated with the activity of the default-mode system (mean r = 0.042, p < 0.001, t(1206) = 20, 95% CI: [0.038, 0.046]), while the activity of subnetwork (B) was negatively correlated with the activity of the default-mode system (mean r = −0.082, p < 0.001, t(1206) = −27, 95% CI: [−0.088, −0.076]). d Using a simple regression model, we tested whether the strength of the functional connection between the default-mode and frontoparietal systems could be predicted by a linear combination of the activity of subnetwork (A) and the activity of subnetwork (B). Within this model, we found that an increase in subnetwork (A) activity corresponds to an increase in the strength of the functional connection between the frontoparietal and default-mode systems (estimate of regression coefficient β = 0.006535, 95% CI: (0.00519, 0.00788), p < 0.001, t(1204) = 9.54). e Conversely, within the same model, we found that an increase in subnetwork (B) activity corresponds to a decrease in the strength of the functional connection between the two systems (estimate of regression coefficient β = −0.0112, 95% CI: (−0.01273, −0.0097), p < 0.001, t(1204) = −14.3).