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. 2020 Jun 15;11:3020. doi: 10.1038/s41467-020-16836-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Schematic representation of human chromosome 17. b Venn diagram of EPN3 and ERBB2 amplification in different BC cohorts: BC METABRIC cohort (N = 2137, available at http://www.cbioportal.org)^71,72, TCGA invasive BC cohort (N = 1080, TCGA Research Network: http://cancergenome.nih.gov/), and the IEO cohort (N = 219). Percentage (%) of amplification is shown in parentheses. In the IEO cohort, EPN3 and ERBB2 were considered amplified when the EPN3/CEP17 ratio was >2.5, and the ERBB2/CEP17 ratio was ≥2.0⁶⁰, respectively. P, P value of the association between the indicated variables by two-sided Fisher’s exact test. c Representative images of EPN3 IHC (quantification scores are indicated). Top, images at 20× (bar, 200 μm); bottom, magnification of the boxed insets (bar, 200 μm). d Venn diagram representation of EPN3 amplification (FISH) and overexpression (IHC; score >1.0) in the IEO cohort (N = 212). P, P value of the association between the indicated variables by two-sided Fisher’s exact test. Source data are provided as a Source Data file.