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. 2020 Jun 9;12:137. doi: 10.3389/fnagi.2020.00137

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Copyright © 2020 Li, Meng, Guo, Niu, Zhao, Wang, Xie and Lv.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dl-3-n-butylphthalide (NBP) alleviates learning and memory deficiency, and the pathologic changes in hippocampal CA 1 region at 4 weeks after 2VO (Morris water maze, n = 9 in each group; Hematoxylin-eosin staining, n = 3 in each group). (A) Escape latency changes in different groups from day 1 to day 5. (B) Changes in time spent in the target quadrant (%) at day 6. (C) Changes in frequency of platform crossings in 2 min at day 6. (D) Swimming path of rats at day 6 in different groups. (E) Representative images of Hematoxylin-eosin staining in the hippocampal CA1 region. *p < 0.05, **p < 0.01, ***p < 0.001, the model group vs. the sham group; ^#p < 0.05, ^##p < 0.01, ^###p < 0.001, the NBP60 group or NBP120 group vs. the model group; ^$p < 0.05, ^$$p < 0.01, the NBP60 group vs. NBP120 group. Values are expressed as mean ± SD.