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Schematic of cell entry of SARS-CoV-2. When the trimeric S proteins of SARS-CoV-2 binds to the cellular receptor ACE2, the cellular serine protease TMPRSS2, which's for S protein priming, entails S protein cleavage at the S1/S2 and the S2' site to facilitates fusion of viral envelop and host cell membranes.
