Figure 2.

(A) Representative HE staining of classical adenocarcinoma (HEx100). For (B–E), representative IHC staining for the four MMR proteins of serial sections from pMMR classical adenocarcinoma (IHCx100). Stromal cells and infiltrating lymphocytes served as internal positive controls. (F) Representative HE staining of dMMR AWMC (HEx100). For (G–J), representative IHC staining for the four MMR proteins of serial sections from dMMR AWMC (IHCx100). Stromal cells and infiltrating lymphocytes served as internal positive controls. In this case, MLH1 and PMS2 were negative. (K) Representative HE staining of AWMC with signet ring cell component (HEx100). For (L–O), representative IHC staining for the four MMR proteins of serial sections from pMMR AWMC with signet ring cell component (IHCx100). Stromal cells and infiltrating lymphocytes served as internal positive controls.