Table 4.
Linear mixed model analysis results (T1, T2, T3, T4).
| Tool | Interaction description | Linear mixed model analysis—interaction effect | ||
|---|---|---|---|---|
| Estimate | Sth Error | p- value | ||
| HAM-D 17 | (Intercept) | 17.346 | 1.017 | 0.000 |
| T4 | −7.024 | 1.352 | 0.000 | |
| Experimental group | −0.484 | 1.401 | 0.730 | |
| T4 time x experimental group | −4.488 | 1.822 | 0.017 | |
| BDI-II total | (Intercept) | 24.000 | 1.782 | 0.000 |
| T2 | −7.160 | 1.481 | 0.000 | |
| T3 | −7.944 | 1.501 | 0.000 | |
| T4 | −5.041 | 1.596 | 0.002 | |
| Experimental group | −2.267 | 2.434 | 0.354 | |
| T2 time x experimental group | −5.007 | 2.008 | 0.014 | |
| T3 time x experimental group | 2.010 | 2.023 | 0.322 | |
| T4 time x experimental group | −2.939 | 2.126 | 0.169 | |
| BDI-II D1 | (Intercept) | 15.385 | 1.346 | 0.000 |
| T2 | −4.427 | 0.944 | 0.000 | |
| T3 | −4.675 | 0.957 | 0.000 | |
| T4 | −2.712 | 1.018 | 0.009 | |
| Experimental group | 1.615 | 1.838 | 0.382 | |
| T2 time x experimental group | −0.906 | 1.279 | 0.480 | |
| T3 time x experimental group | −2.192 | 1.289 | 0.091 | |
| T4 time x experimental group | −5.087 | 1.355 | 0.000 | |
| BDI-II D2 | (Intercept) | 8.615 | 0.706 | 0.000 |
| T2 | −2.711 | 0.660 | 0.000 | |
| T3 | −3.246 | 0.669 | 0.000 | |
| T4 | −2.341 | 0.711 | 0.001 | |
| Experimental group | 0.451 | 0.964 | 0.641 | |
| T2 time x experimental group | 0.011 | 0.896 | 0.990 | |
| T3 time x experimental group | −0.154 | 0.902 | 0.865 | |
| T4 time x experimental group | −2.106 | 0.948 | 0.028 | |
| WHOQoL D1 | (Intercept) | 37.154 | 3.407 | 0.000 |
| T4 | 7.270 | 3.644 | 0.052 | |
| Experimental group | 1.514 | 4.682 | 0.747 | |
| T4 time x experimental group | 9.670 | 4.870 | 0.053 | |
| WHOQoL D2 | (Intercept) | 38.538 | 3.511 | 0.000 |
| T4 | 5.292 | 3.772 | 0.167 | |
| Experimental group | 2.157 | 4.825 | 0.656 | |
| T4 time x experimental group | 9.527 | 5.041 | 0.065 | |
| WHOQoL D3 | (Intercept) | 44.077 | 4.083 | 0.000 |
| T4 | −4.720 | 4.068 | 0.252 | |
| Experimental group | 3.346 | 5.607 | 0.552 | |
| T4 time x experimental group | 15.869 | 5.432 | 0.005 | |
| WHOQoL D4 | (Intercept) | 48.692 | 3.400 | 0.000 |
| T4 | 4.205 | 2.482 | 0.096 | |
| Experimental group | 9.122 | 4.418 | 0.044 | |
| EQ-5D | (Intercept) | 7.750 | 0.409 | 0.000 |
| T4 | −0.037 | 0.571 | 0.948 | |
| Experimental group | −0.150 | 0.559 | 0.789 | |
| T4 time x experimental group | −0.509 | 0.757 | 0.504 | |
| AIS | (Intercept) | 25.115 | 1.732 | 0.000 |
| T4 | −3.958 | 2.219 | 0.080 | |
| Experimental group | −2.015 | 2.366 | 0.397 | |
| T4 time x experimental group | 8.383 | 2.958 | 0.007 | |
| VAS 1 | (Intercept) | 3.508 | 0.399 | 0.000 |
| T2 | 1.321 | 0.351 | 0.000 | |
| T3 | 1.539 | 0.361 | 0.000 | |
| Experimental group | −0.378 | 0.545 | 0.490 | |
| T2 time x experimental group | 0.452 | 0.475 | 0.344 | |
| T3 time x experimental group | 1.031 | 0.483 | 0.035 | |
| VAS 2 | (Intercept) | 3.492 | 0.375 | 0.000 |
| T2 | 1.604 | 0.328 | 0.000 | |
| T3 | 1.534 | 0.338 | 0.000 | |
| Experimental group | −0.026 | 0.513 | 0.960 | |
| T2 time x experimental group | −0.117 | 0.445 | 0.793 | |
| T3 time x experimental group | 0.559 | 0.453 | 0.219 | |
| VAS 3 | (Intercept) | 3.996 | 0.445 | 0.000 |
| T2 | 1.427 | 0.426 | 0.001 | |
| T3 | 1.399 | 0.445 | 0.002 | |
| Experimental group | −0.003 | 0.607 | 0.996 | |
| T2 time x experimental group | −0.970 | 0.578 | 0.096 | |
| T3 time x experimental group | 0.414 | 0.592 | 0.486 | |
| SLSQ | (Intercept) | 24.236 | 1.159 | 0.000 |
| T2 | 0.084 | 0.899 | 0.926 | |
| T3 | 1.237 | 0.913 | 0.177 | |
| T4 | 1.216 | 0.998 | 0.225 | |
| Experimental group | −0.103 | 1.563 | 0.948 | |
| T2 time x experimental group | 1.383 | 1.210 | 0.255 | |
| T3 time x experimental group | 1.296 | 1.220 | 0.290 | |
| T4 time x experimental group | 1.397 | 1.303 | 0.286 | |
HAM-D 17, Hamilton Depression Rating Scale; BDI-II, Beck Depression Inventory-II; WHOQoL, World Health Organization Quality of Life; VAS, Visual Analog Scales; AIS, Acceptance of Illness Scale; SLSQ, The Sexual Life Satisfaction Questionnaire.