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. 2020 Jun 9;11:1215. doi: 10.3389/fmicb.2020.01215

FIGURE 4.

FIGURE 4

Serum circRNA expression signature for TB diagnosis in the validation phase. (A–C) The expression of circRNA_051239, circRNA_029965, and circRNA_404022 in serum from active TB patients (N = 72), CAP patients (N = 30), and healthy controls (N = 30) by qRT-PCR. (D–F) ROC curve analysis for circRNA_051239, circRNA_029965, and circRNA_404022 in serum from active TB patients (N = 128, including training set and validation set), CAP patients (N = 50, including training set and validation set), and healthy controls (N = 50, including training set and validation set). (G) ROC curve analysis for the combined circRNAs panel in serum from active TB patients (N = 128, including training set and validation set), CAP patients (N = 50, including training set and validation set), and healthy controls (N = 50, including training set and validation set). Each value is the mean ± SD; ***P < 0.001.