Table 2.
Potential roles of proteins in glioblastoma.
| Protein | Relevance to GBM | Reference |
|---|---|---|
| TIMP1 | Expressed in tumor and vascular cells | 53 |
| SERPINE1 | Expressed in vascularized regions | 54 |
| TSP1 | Expressed in tumor and vascular cells | 55, 58 |
| HGF | Expressed in tumor and vascular cells, supports proliferation, migration, and therapeutic resistance | 56, 64 |
| uPA | Expressed in tumor and vascular cells, may support invasion and MMP activation | 57, 61 |
| IL8 | Secreted by endothelial cells, supports cancer stem cell self-renewal and invasion | 37, 60 |
| IGFBP2 | Supports proliferation, migration, and therapeutic resistance | 59 |
| SERPINF1 | May promote cancer stem cell self-renewal | 62, 63 |