Table 8.
Multivariable Logistic Regression Models for HP and Psychosocial and Neurocognitive Health Outcomes
| Clinical Outcome (Yes) | GHD | TSHD | Untreated LH/FSHD | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GHD | No GHD | Multivariable Analysis | TSHD | No TSHD | Multivariable Analysis | LH/FSHD | No LH/FSHD | Multivariable Analysis | ||||||||
| No. (%) | No. (%) | No. (%) | OR | 95% CI | P Value | No. (%) | No. (%) | OR | 95% CI | P Value | No. (%) | No. (%) | OR | 95% CI | P Value | |
| Psychosocial health outcome | ||||||||||||||||
| PCS (n = 2036)a | 359 (17.6) | 84 (20.1) | 275 (17.0) | 1.26 | 0.91 to 1.75 | 0.16 | 31 (29.5) | 328 (17.0) | 2.38 | 1.45 to 3.92 | 0.0007 | 18 (24.7) | 341 (17.4) | 1.03 | 0.57 to 1.89 | 0.91 |
| GSI (n = 2051)b | 291 (14.2) | — | — | — | — | — | 14 (9.9) | 277 (14.5) | 0.89 | 0.49 to 1.61 | 0.70 | — | — | — | — | — |
| Anxiety (n = 2052)b | 242 (11.8) | — | — | — | — | — | 9 (6.3) | 233 (12.2) | 0.68 | 0.33 to 1.38 | 0.29 | — | — | — | — | — |
| Depression (n = 1992)b | 300 (15.1) | — | — | — | — | — | — | — | — | — | — | 17 (23.9) | 283 (14.7) | 1.75 | 0.97 to 3.14 | 0.06 |
| Sexual dysfunction (n = 1337)c | 438 (32.8) | 104 (40.0) | 334 (31.0) | 1.29 | 0.96 to 1.74 | 0.10 | 36 (46.8) | 402 (31.9) | 1.44 | 0.87 to 2.38 | 0.15 | 25 (54.4) | 413 (32.0) | 2.05 | 1.09 to 3.83 | 0.03 |
| Male sexual dysfunction (n = 645) | 177 (27.4) | 48 (33.3) | 129 (25.8) | 1.31 | 0.86 to 1.99 | 0.20 | — | — | — | — | — | 14 (42.4) | 163 (26.6) | 2.06 | 0.98 to 4.35 | 0.06 |
| Female sexual dysfunction (n = 692) | 261 (37.7) | 56 (48.3) | 205 (35.6) | 1.40 | 0.90 to 2.16 | 0.13 | 23 (50.0) | 238 (36.8) | 1.13 | 0.58 to 2.21 | 0.72 | 250 (36.8) | 11 (84.6) | 6.91 | 1.43 to 33.42 | 0.02 |
| Neurocognitive health outcomed | ||||||||||||||||
| Memory (n = 1370) | 290 (21.2) | 85 (37.8) | 205 (17.9) | 1.74 | 1.21 to 2.52 | 0.003 | 34 (54.8) | 256 (19.6) | 3.46 | 1.91 to 6.27 | <0.0001 | 15 (31.3) | 275 (20.8) | 0.56 | 0.27 to 1.15 | 0.11 |
| Attention (n = 1403) | 255 (18.2) | 62 (24.1) | 193 (16.8) | 1.12 | 0.75 to 1.67 | 0.57 | 27 (30.7) | 228 (17.3) | 1.63 | 0.95 to 2.79 | 0.08 | — | — | — | — | — |
| Processing speed (n = 1173) | 84 (7.2) | 38 (17.0) | 46 (4.9) | 1.80 | 1.01 to 3.21 | 0.05 | 19 (25.7) | 65 (5.9) | 2.12 | 1.07 to 4.21 | 0.03 | — | — | — | — | — |
| Executive function (n = 1194) | 275 (23.0) | 79 (34.1) | 196 (20.4) | 1.14 | 0.77 to 1.67 | 0.52 | 33 (41.3) | 242 (21.7) | 1.55 | 0.90 to 2.66 | 0.11 | |||||
Abbreviations: GSI, Global Severity Index; MCS, Mental Component Summary; PCS, Physical Component Summary.
PCS was adjusted for sex, age at SJLIFE, and cranial radiation therapy.
All parameters of emotional distress (i.e., GSI, anxiety, and depression) were adjusted for age at SJLIFE, sex, cranial radiation therapy, excessive alcohol use, illicit drug use, and smoking status.
Psychosexual dysfunction was adjusted for age at SJLIFE and ethnicity/race.
All four neurocognitive health outcomes were adjusted for cranial radiation therapy. Initially, the interaction term cranial radiation therapy dose and HP disorders was included in the model; however, the P value was >0.1, suggesting that this interaction term should not be included in the final model.