Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jun 9;10:245. doi: 10.3389/fcimb.2020.00245

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Poole, Neves, Oliveira, Sinclair and da Silva.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Biological properties of cmvIL10 in myeloid progenitors (during lytic infection). cmvIL10 secreted by bystander infected cells binds to the cIL10 receptor in myeloid progenitors inducing phosphorylation of STAT3 on Tyr 705. cmvIL10 also activates the PI3K pathway leading to phosphorylation of STAT3 on S727. Phosphorylated STAT3 activates downstream signaling. Green vertical arrows indicate molecules up or downregulated upon signaling and red arrows point to pathways induced or inhibited by LAcmvIL10.