Table 4.
Expression profile of known T. parva antigens.
| Locus tag ID | Antigen name | TPM values | Product name | Domains | ||||
|---|---|---|---|---|---|---|---|---|
| Sporoblast* | Sporozoite* | Schizont* | Schizont | Piroplasm | ||||
| TP03_0849 | Tp1 | 111 | 990 | 155 | 320 | 201 | CD8+ T-cell target antigen | SP |
| TP01_0056 | Tp2 | 309 | 1,427 | 625 | 533 | 39 | CD8+ T-cell target antigen | SP |
| TP01_0868 | Tp3 | 280 | 61 | 145 | 25 | 176 | CD8+ T-cell target antigen | SP |
| TP03_0210 | Tp4 | 369 | 431 | 242 | 309 | 199 | T-complex protein 1 subunit eta | (-) |
| TP02_0767 | Tp5 | 702 | 503 | 292 | 249 | 175 | Translation initiation factor eIF-1A | (-) |
| TP01_0188 | Tp6 | 475 | 261 | 275 | 248 | 151 | Prohibitin | SP |
| TP02_0244 | Tp7 | 2,363 | 2,324 | 803 | 2,034 | 1,067 | Heat shock protein 90 | (-) |
| TP02_0140 | Tp8 | 3,146 | 1,658 | 4,315 | 3,044 | 2,740 | Cysteine proteinase | SP |
| TP02_0895 | Tp9 | 273 | 6,384 | 1,497 | 708 | 5 | CD8+ T-cell target antigen | SP |
| TP04_0772 | Tp10 | 954 | 515 | 1,090 | 300 | 290 | Coronin | (-) |
| TP03_0287 | p67 | 17,464 | 840 | 21 | 3 | 0 | Hypothetical protein | SP, 1 TMD |
| TP04_0051 | PIM | 322 | 3,361 | 961 | 2,661 | 905 | Polymorphic immunodominant molecule | SP, 3 TMD |
| TP01_0939 | gp34 | 24 | 261 | 113 | 101 | 113 | Hypothetical protein | SP, 1 TMD |
| TP04_0437 | p104 | 15 | 11,151 | 539 | 395 | 39 | 104 kDa microneme/rhoptry antigen | SP, GPI |
| TP03_0445 | PCNA | 1,225 | 102 | 271 | 337 | 102 | Proliferating cell nuclear antigen | (-) |
| TP02_0600 | PCNA | 710 | 49 | 420 | 314 | 181 | Proliferating cell nuclear antigen | NLS |
*
Data from Tonui et al. (16).
The p67 TPM value was considered as background and was subtracted from the expression value of each antigen. GPI, GPI anchor; NLS, nuclear localization signal; PIM, polymorphic immunodominant molecule; (-), none.