Table 5.
Top 20 T. parva surface proteins with high antibody epitope prediction values and with expression similar to known antigen.
| Gene ID | Protein ID | SP | SZ | Sca | Scb | PRM | ESA | DM | Name | SLP | NE | HPRS |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TP03_0513 | XP_763541.1 | 150 | 800 | 335 | 296 | 199 | Tp1 | 5 TMD | HP | PM | 7 | 0.749 |
| TP02_0615 | XP_765181.1 | 345 | 174 | 14 | 9 | 31 | Tp3 | 7 TMD | RING-type domain-containing protein | PM | 20 | 0.738 |
| TP03_0544 | XP_763572.1 | 32 | 1,568 | 360 | 203 | 98 | Tp2 | 10 TMD | HP | PM | 6 | 0.717 |
| TP01_1200 | XP_766721.1 | 295 | 22 | 97 | 49 | 13 | Tp3 | 7 TMD | Phosphodiesterase | PM | 11 | 0.711 |
| TP02_0232 | XP_764798.1 | 503 | 1,387 | 266 | 274 | 19 | Tp2 | 11 TMD | HP | PM | 10 | 0.709 |
| TP01_0509 | XP_766029.1 | 104 | 339 | 134 | 163 | 99 | gp34 | SP, 1 TMD | HP | ES | 13 | 0.709 |
| TP03_0168 | XP_763186.1 | 91 | 437 | 639 | 358 | 108 | Tp4 | SP, 1 TMD | HP | PM | 88 | 0.703 |
| TP03_0165 | XP_763183.1 | 19 | 366 | 123 | 131 | 3 | gp34 | 9 TMD | ABC transporter | NS | 34 | 0.702 |
| TP01_1013 | XP_766534.1 | 146 | 310 | 96 | 88 | 165 | gp34 | SP, 7 TMD | MtN3/RAG1IP protein | PM | 9 | 0.700 |
| TP04_0448 | XP_764083.1 | 276 | 22 | 28 | 25 | 76 | Tp3 | 8 TMD | HP | PM | 21 | 0.699 |
| TP01_0506 | XP_766026.1 | 145 | 556 | 242 | 195 | 162 | Tp4 | SP, 1 TMD | GOLD domain-containing protein | ES | 7 | 0.679 |
| TP04_0076 | XP_763711.1 | 4,952 | 608 | 727 | 907 | 1,097 | Tp7 | 2 TMD | HP | PM | 2 | 0.677 |
| TP02_0183 | XP_764747.1 | 62 | 288 | 151 | 112 | 97 | gp34 | 9 TMD | HP | PM | 21 | 0.674 |
| TP04_0803 | XP_764440.1 | 98 | 370 | 318 | 236 | 205 | Tp4 | 8 TMD | TPT domain-containing protein | PR | 11 | 0.659 |
| TP03_0287 | XP_763305.1 | 17,465 | 840 | 21 | 3 | 2 | p67 | SP, 1 TMD | HP | PM-ES | 18 | 0.658 |
| TP03_0175 | XP_763193.1 | 1,063 | 42 | 21 | 90 | 147 | PCNA | SP, TMD | HP | ES | 18 | 0.658 |
| TP04_0907 | XP_764544.1 | 3 | 336 | 102 | 91 | 6 | gp34 | 18 TMD | HP | PR | 23 | 0.652 |
| TP03_0895 | XP_763368.1 | 61 | 308 | 432 | 256 | 121 | Tp4 | 12 TMD | Folate/biopterin transporter | PM | 17 | 0.650 |
| TP03_0455 | XP_763475.1 | 238 | 17 | 61 | 64 | 119 | Tp3 | SP, 6 TMD | HP | PM | 10 | 0.645 |
| TP04_0640 | XP_764275.1 | 136 | 8,957 | 671 | 794 | 202 | p104 | 1 TMD | HP | PM | 2 | 0.566 |
*p67 antigen is used as reference for the prediction value. SP, sporoblast; SZ, sporozoite; SCa, schizont a; Scb, schizont b; PRM, piroplasm; DM, domain; ES, extracellular localization; ESA, expression similar to known antigen; HP, hypothetical protein; HPRS, highest epitope predicted residue scores; NE, number of predicted epitopes; PM, plasma membrane; NS, nucleus; PR, peroxisome; SLP, subcellular localization prediction.