Table 1.
Gene sets of signaling molecule(s)/receptor/pseudo-receptor for secondary metabolite production in Streptomyces species.
| Signaling molecule synthesis gene | Signaling molecule(s) | Receptor gene | Pseudo-receptor gene (pI of gene product) | Secondary metabolite(s) | |
|---|---|---|---|---|---|
| S. griseus | afsA | A-factor | arpA | Streptomycin, grixazone | |
| S. rochei | srrX | SRB1, SRB2 | srrA | srrB (11.2) | Lankacidin, lankamycin |
| S. fradiae | ND | ND | tylP | tylQ (6.4) | Tylosin |
| S. coelicolor | scbA | SCB1-3 | scbR | scbR2 (5.8) | Coelimycin P-1, actinorhodin, undecylprodigiosin |
| S. coelicolor | mmfL | MMFs | mmfR | Methylenomycin | |
| S. virginiae | barX | Virginia butanolides | barA | barB (10.2) | Virginiamycin |
| S. venezuelae | jadW1 | SVB1 | jadR3 | jadR2 (7.8) | Jadomycin |
| S. lavendulae | farA | IM-2 | farR | farR2 (9.7) | Showdomycin |
| S. ambofaciens | ND | ND | alpZ | alpW (11.6) | Kinamycins |
| S. avermitilis | aco | Avenolide | avaR1 | avaR2 (9.6) | Avermectins |
ND, Not determined.