Table 2.
Results of statistical hypothesis testing comparing discordant MZ twins with high and low heat pain sensitivity, using the MLR approach correcting for chronological age, and including family as a random effect.
| Epigenetic Variable | Coefficient | P-value | P-value LocAdjBH | P-value GlobAdjBH |
|---|---|---|---|---|
| DNAmAge | 0.862 | 0.376 | 0.571 | 0.958 |
| DNAmAgeHannum | 1.779 | 0.163 | 0.449 | 0.942 |
| DNAmAgeSkinBloodClock | 0.789 | 0.381 | 0.571 | 0.958 |
| DNAmPhenoAge | 1.925 | 0.153 | 0.449 | 0.942 |
| DNAmGrimAge | 0.611 | 0.318 | 0.571 | 0.958 |
| DNAmTL | −0.020 | 0.331 | 0.571 | 0.958 |
| DNAmADM | 4.194 | 0.168 | 0.449 | 0.942 |
| DNAmB2M | 14611.748 | 0.410 | 0.579 | 0.967 |
| DNAmCystatinC | 3930.380 | 0.377 | 0.571 | 0.958 |
| DNAmGDF15 | −43.823 | 0.150 | 0.449 | 0.942 |
| DNAmLeptin | 1124.843 | 0.313 | 0.571 | 0.958 |
| DNAmPAI1 | 733.414 | 0.189 | 0.455 | 0.942 |
| DNAmTIMP1 | 20.035 | 0.877 | 0.915 | 0.995 |
| DNAmPACKYRS | 0.710 | 0.613 | 0.736 | 0.995 |
| CD8T | −0.022 | 0.028 | 0.449 | 0.942 |
| CD4T | −0.002 | 0.902 | 0.915 | 0.995 |
| CD8.naive | −0.612 | 0.915 | 0.915 | 0.995 |
| CD4.naive | −29.158 | 0.072 | 0.449 | 0.942 |
| CD8pCD28nCD45RAn | −0.592 | 0.451 | 0.601 | 0.967 |
| NK | −0.006 | 0.597 | 0.736 | 0.995 |
| Bcell | −0.009 | 0.118 | 0.449 | 0.942 |
| Mono | 0.002 | 0.703 | 0.803 | 0.995 |
| Gran | 0.033 | 0.098 | 0.449 | 0.942 |
| PlasmaBlast | 0.068 | 0.074 | 0.449 | 0.942 |
The columns report the value of MLR coefficient (“Coefficient”), the corresponding nominal p-value (“P-value”), the p-value corrected with Benjamini–Hochberg procedure for multiple tests locally—within a single cohort (“P-value LocAdjBH”), and globally—within all the cohorts included in the study (“P-value GlobAdjBH”). Significant p-values are reported in bold.