Table 3.
Results of association analysis between epigenetic measurements and HPST values in the HPS cohort, correcting for chronological age, and including family as a random effect.
| Epigenetic variable | Coefficient | P-value | P-value LocAdjBH | P-value GlobAdjBH |
|---|---|---|---|---|
| DNAmAge | 0.038 | 0.872 | 0.947 | 0.995 |
| DNAmAgeHannum | 0.231 | 0.452 | 0.947 | 0.967 |
| DNAmPhenoAge | 0.135 | 0.677 | 0.947 | 0.995 |
| DNAmAgeSkinBloodClock | 0.093 | 0.671 | 0.947 | 0.995 |
| DNAmGrimAge | 0.143 | 0.332 | 0.947 | 0.958 |
| DNAmADM | 0.874 | 0.182 | 0.947 | 0.942 |
| DNAmB2M | −882.527 | 0.831 | 0.947 | 0.995 |
| DNAmCystatinC | 452.914 | 0.648 | 0.947 | 0.995 |
| DNAmGDF15 | −16.463 | 0.007 | 0.159 | 0.757 |
| DNAmLeptin | 394.685 | 0.113 | 0.947 | 0.942 |
| DNAmPAI1 | 190.268 | 0.126 | 0.947 | 0.942 |
| DNAmTIMP1 | −7.918 | 0.777 | 0.947 | 0.995 |
| DNAmPACKYRS | 0.243 | 0.483 | 0.947 | 0.991 |
| DNAmTL | 0.000 | 0.985 | 0.985 | 0.995 |
| CD8T | −0.001 | 0.646 | 0.947 | 0.995 |
| CD4T | 0.001 | 0.807 | 0.947 | 0.995 |
| CD8.naive | −0.163 | 0.908 | 0.947 | 0.995 |
| CD4.naive | −4.764 | 0.246 | 0.947 | 0.958 |
| CD8pCD28nCD45RAn | −0.153 | 0.417 | 0.947 | 0.967 |
| NK | −0.001 | 0.750 | 0.947 | 0.995 |
| Bcell | 0.000 | 0.725 | 0.947 | 0.995 |
| Mono | 0.000 | 0.781 | 0.947 | 0.995 |
| Gran | 0.002 | 0.630 | 0.947 | 0.995 |
| PlasmaBlast | 0.007 | 0.389 | 0.947 | 0.958 |
The columns report the value of regression coefficient (“Coefficient”), the corresponding nominal p-value (“P-value”), the p-value corrected with Benjamini–Hochberg procedure for multiple tests locally—within a single cohort (“P-value LocAdjBH”), and globally—within all the cohorts included in the study (“P-value GlobAdjBH”). Significant p-values are reported in bold.