Table 4.

Results of statistical hypothesis testing comparing FM patients and healthy individuals (HC), using the MLR approach correcting for chronological age.

Epigenetic variable	Coefficient	P-value	P-value LocAdjBH	P-value GlobAdjBH
DNAmAge	−2.168	0.449	0.963	0.967
DNAmAgeHannum	1.109	0.717	0.963	0.995
DNAmAgeSkinBloodClock	−0.662	0.814	0.963	0.995
DNAmPhenoAge	−0.971	0.736	0.963	0.995
DNAmGrimAge	−0.449	0.692	0.963	0.995
DNAmTL	0.030	0.676	0.963	0.995
DNAmADM	4.512	0.280	0.963	0.958
DNAmB2M	−4734.247	0.889	0.969	0.995
DNAmCystatinC	−10037.097	0.180	0.963	0.942
DNAmGDF15	−1.171	0.979	0.979	0.995
DNAmLeptin	−536.235	0.684	0.963	0.995
DNAmPAI1	−59.495	0.940	0.979	0.995
DNAmTIMP1	−47.894	0.843	0.963	0.995
DNAmPACKYRS	−1.560	0.649	0.963	0.995
CD8T	0.010	0.422	0.963	0.967
CD4T	0.009	0.610	0.963	0.995
CD8.naive	13.099	0.360	0.963	0.958
CD4.naive	67.771	0.025	0.599	0.942
CD8pCD28nCD45RAn	−0.330	0.753	0.963	0.995
NK	−0.017	0.171	0.963	0.942
Bcell	−0.006	0.415	0.963	0.967
Mono	0.002	0.750	0.963	0.995
Gran	−0.007	0.788	0.963	0.995
PlasmaBlast	0.047	0.361	0.963	0.958

The columns report the value of MLR coefficient (“Coefficient”), the corresponding nominal p-value (“P-value”), the p-value corrected with Benjamini–Hochberg procedure for multiple tests locally—within a single cohort (“P-value LocAdjBH”), and globally—within all the cohorts included in the study (“P-value GlobAdjBH”). Significant p-values are reported in bold.