Table 6.

Results of statistical hypothesis testing comparing MOH patients, EM patients, and healthy individuals (HC), using the MLR approach correcting for chronological age.

	MOH vs. HC				EM vs. HC				MOH vs. EM
Epigenetic variable	Coefficient	P-value	P-value LocAdjBH	P-value GlobAdjBH	Coefficient	P-value	P-value LocAdjBH	P-value GlobAdjBH	Coefficient	P-value	P-value LocAdjBH	P-value GlobAdjBH
DNAmAge	0.066	0.954	0.968	0.995	2.157	0.199	0.606	0.942	2.354	0.091	0.721	0.942
DNAmAgeHannum	−1.708	0.378	0.824	0.958	1.975	0.313	0.751	0.958	0.701	0.712	0.912	0.995
DNAmAgeSkinBloodClock	0.539	0.610	0.915	0.995	0.023	0.986	0.986	0.995	1.009	0.331	0.721	0.958
DNAmPhenoAge	0.211	0.896	0.968	0.995	0.902	0.662	0.962	0.995	1.869	0.281	0.721	0.958
DNAmGrimAge	−0.785	0.583	0.915	0.995	1.598	0.175	0.606	0.942	0.855	0.493	0.845	0.994
DNAmTL	0.031	0.531	0.915	0.995	−0.007	0.903	0.985	0.995	0.011	0.798	0.912	0.995
DNAmADM	0.155	0.968	0.968	0.995	−1.918	0.678	0.962	0.995	−0.166	0.956	0.956	0.995
DNAmB2M	−35367.502	0.210	0.682	0.942	6664.817	0.832	0.962	0.995	−34406.624	0.195	0.721	0.942
DNAmCystatinC	−6991.375	0.227	0.682	0.945	353.046	0.953	0.986	0.995	−4276.995	0.349	0.721	0.958
DNAmGDF15	−8.906	0.860	0.968	0.995	10.909	0.842	0.962	0.995	−5.230	0.905	0.945	0.995
DNAmLeptin	−2140.873	0.297	0.771	0.958	2859.149	0.199	0.606	0.942	1191.950	0.361	0.721	0.958
DNAmPAI1	−1622.909	0.101	0.682	0.942	1178.540	0.389	0.847	0.958	−266.931	0.755	0.912	0.995
DNAmTIMP1	−79.089	0.542	0.915	0.995	−43.855	0.741	0.962	0.995	−57.791	0.672	0.912	0.995
DNAmPACKYRS	1.707	0.681	0.961	0.995	4.488	0.189	0.606	0.942	4.935	0.188	0.721	0.942
CD8T	−0.015	0.123	0.682	0.942	0.014	0.220	0.606	0.945	−0.002	0.845	0.922	0.995
CD4T	−0.003	0.792	0.968	0.995	0.023	0.206	0.606	0.942	0.014	0.337	0.721	0.958
CD8.naive	1.768	0.862	0.968	0.995	2.456	0.823	0.962	0.995	2.767	0.768	0.912	0.995
CD4.naive	43.989	0.146	0.682	0.942	13.125	0.680	0.962	0.995	45.008	0.105	0.721	0.942
CD8pCD28nCD45RAn	0.901	0.198	0.682	0.942	−1.173	0.117	0.606	0.942	−0.182	0.789	0.912	0.995
NK	−0.014	0.152	0.682	0.942	0.003	0.823	0.962	0.995	−0.009	0.309	0.721	0.958
Bcell	0.007	0.321	0.771	0.958	0.003	0.630	0.962	0.995	0.012	0.048	0.721	0.942
Mono	−0.004	0.427	0.853	0.967	−0.008	0.227	0.606	0.945	−0.008	0.120	0.721	0.942
Gran	0.030	0.106	0.682	0.942	−0.036	0.210	0.606	0.942	−0.008	0.723	0.912	0.995
PlasmaBlast	0.002	0.964	0.968	0.995	−0.039	0.424	0.847	0.967	−0.036	0.431	0.796	0.967

The columns report the value of MLR coefficient (“Coefficient”), the corresponding nominal p-value (“P-value”), the p-value corrected with Benjamini–Hochberg procedure for multiple tests locally—within a single cohort (“P-value LocAdjBH”), and globally—within all the cohorts included in the study (“P-value GlobAdjBH”).