Table 2.

Antiinflammatory activity of 3–6 with a carrageenan oral model. Test compounds: 25 mg/kg.^a

treatment	paw edema (mm)b	% inhibition	Pa	clogPc
carrageenan	0.830 ± 0.017d	–	–	–
indomethacin (20 mg/kg)	0.530 ± 0.04d	36.1	–	–
3	0.626 ± 0.03d,e	24.6	0.77	0.58
4	0.657 ± 0.02d,e	20.9	0.71	1.39
5	0.716 ± 0.03d,e	13.8	0.66	1.80
6	0.755 ± 0.06e	9.1	0.63	1.85

^aThe data is presented as mean ± standard error (s.e.). The percentage of inhibition of the edema is in respect to the carrageenan group. Statistical analysis one-way ANOVA, post hoc SNK test (p ≤ 0.05). ^bAt 5 h. ^cCalculated using Molinspiration property engine v2018.10b [31]. ^dVs control carrageenan. ^eVs indomethacin; n = 5.