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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2020 Apr 9;40(6):1533–1542. doi: 10.1161/ATVBAHA.120.314146

Figure 7.

Figure 7.

(A) Mean plasma concentration-time curve of AM in WT lean and WT DIO mice after a single oral dose of 0.5mg/kg DT-678. Plasma AM (n=6 each) was quantified as described in Materials and Methods. The PK parameters were obtained by fitting the data to a non-compartmental model using PKSolver. WT DIO mice showed higher peak AM concentrations (WT DIO= 127.9.2 ± 11.72 vs. WT lean= 63.22 ± 7.862 ng/ml, p <0.01) and higher AUC (WT DIO= 48.03 ± 3.286 vs. WT lean= 27.01 ± 1.351 ng*h/ml, p <0.001) compared to WT lean mice. (B, C) Liver GSH content in WT lean and WT DIO mice. n=5 each. Data were analyzed by unpaired t-test. ns=not significant. GSH= glutathione.