Table 3. Multivariable Analysis.
| Variable | Ibuprofen over nonintervention, aOR (95% CI)a | ||
|---|---|---|---|
| Total (n = 142) | Gestational age | ||
| 23-26 wk (n = 80) | 27-30 wk (n = 62)b | ||
| BPD or death | 1.61 (0.72-3.63) | 1.25 (0.43-3.59) | 2.34 (0.61-8.87) |
| BPD | 1.48 (0.64-3.41) | 1.25 (0.43-3.62) | 1.94 (0.49-7.67) |
| Death before hospital discharge | 1.14 (0.32-4.04) | 0.70 (0.15-3.13) | NA |
| IVH (grade ≥III) | 0.50 (0.08-3.25) | 0.17 (0.01-4.19) | NA |
| ROP (stage ≥3) | 1.00 (0.41-2.48) | 1.08 (0.41-2.86) | 0.94 (0.05-17.60) |
| NEC (stage ≥IIb) | 2.52 (0.60-10.52) | 1.46 (0.29-7.26) | NA |
| Gastrointestinal surgery | 1.66 (0.54-5.14) | 0.83 (0.22-3.17) | NA |
| Sepsis | 3.60 (0.91-14.24) | 3.19 (0.75-13.52) | NA |
| Ductal closure | |||
| 1 wk After randomization | 8.77 (2.08-36.87) | 4.14 (0.28-58.70) | 11.07 (1.82-67.30) |
| Before 36 wk PMA | 1.38 (0.59-3.21) | 1.08 (0.32-3.66) | 1.94 (0.55-6.82) |
| Before hospital discharge | 1.90 (0.69-5.21) | 1.07 (0.23-4.88) | 3.12 (0.75-12.91) |
Abbreviations: aOR, adjusted odds ratio; BPD, bronchopulmonary dysplasia; IVH, intraventricular hemorrhage; NA, not applicable; NEC, necrotizing enterocolitis; PMA, postmenstrual age; ROP, retinopathy of prematurity.
a
Odds ratio adjusted by gestational age, sex, Apgar score at 5 minutes, multiple birth, premature rupture of membranes (≥24 hours), and chorioamnionitis.
b
NA indicates that there were insufficient numbers to calculate the aORs.