Fig. 6.

Photomicrograph of sections of cerebral cortex of rats. H&E reveals well organized structure with neurons having rounded pale nuclei and basophilic cytoplasm in Con, PE and PE Nano. Disturbed structure, shrunk neurons with condensed pyknotic nuclei (arrow) and areas of hyaline degeneration (head arrow) noted in AD. Sections of AD treated with PE and PE Nano formulation or PE + AD reveals restoration of the well-organized structure of the cortex and the neurons. The cresyl violet stain shows prominent basophilic Nissl’s granules in the cytoplasm of neurons (arrows) present in Con, PE and PE Nano formulation. In AD, chromatolysis is evident (dashed arrows). Nissle granules is restored in sections of PE Nano formulation or PE + AD but partly in AD + PE (arrows). Silver stain shows numerous NFT (arrows) and SP (circles) in AD sections. NFT (arrows) appeared to decrease in AD + PE or PE nano but disappeared in PE + AD. (H&E X200, Cresyl violet and silver X600).