Table 1. IC50 Values Determined against NDM-1, VIM-2, and IMP-28.
| IC50 (μM)a |
|||
|---|---|---|---|
| compound | NDM-1 | VIM-2 | IMP-28 |
| 1 | >200 | >200 | >200 |
| 2 | 75 ± 2 | 41 ± 6 | >200 |
| 3 | 1.3 ± 0.07 | 2.4b | 112 ± 3 |
| 4 | 2.3 ± 0.05 | 25b | >200 |
| 5 | 0.91 ± 0.05 | 0.68 ± 0.02 | 39 ± 7 |
| 6 | >200 | >200 | >200 |
| 7 | >200 | >200 | >200 |
| 8 | 132 ± 15 | 102 ± 7 | >200 |
| DPA | 3.8 ± 0.04 | 2.9 ± 0.5 | 17 ± 1 |
a
Values reported as mean ± SD of at least 3 independent experiments.
b
Due to the complex shape of the log[concentration] – activity plot, accurate fitting was not possible; the reported values are therefore an estimation (see the Supporting Information).