Table 2. ITC Based Thermodynamic Parameters for the Binding of Zinc by Compounds 3–5.
compound | Kd (nM) | ΔH (kcal/mol) | –TΔS (kcal/mol) | ΔG (kcal/mol) |
---|---|---|---|---|
3 | 121 ± 7 | –4.890 ± 0.219 | –4.546 ± 0.248 | –9.400 ± 0.042 |
4 | 231 ± 10 | –2.957 ± 0.069 | –6.100 ± 0.079 | –9.057 ± 0.026 |
5 | 56 ± 15 | –3.077 ± 0.113 | –6.837 ± 0.274 | –9.910 ± 0.155 |