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Interactions of RanBP9 with APP, LRP, and BACE1. RanBP9 promotes the endocytosis of APP and considerably increases its BACE1 cleavage to generate Aβ fragments. RanBP9 exerts pro-apoptotic activity by regulating B-cell lymphoma 2 (Bcl-2) and Bcl-2-associated X (Bax) protein levels in mitochondria. RanBP9 and p73 together induce abnormal changes in mitochondria (MMP, superoxide levels, apoptotic proteins, and fission) and bring about apoptosis.
