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. 2020 Feb 19;3(3):535–546. doi: 10.1021/acsptsci.0c00002

Figure 4.

Figure 4

Comparative efficacy of Pn3a and analogues in a mouse model of NaV1.7 mediated pain. (A) Local injection of Pn3a (WT) and analogues (i.pl., 1 μM) reverses spontaneous pain behaviors induced by i.pl. injection of the NaV1.7 activator OD1 in mice; n = 5–6 per group. (B) Systemic administration of Pn3a (WT) and analogues (i.p., 1 mg/kg) reverses spontaneous pain behaviors induced by i.pl. injection of the NaV1.7 activator OD1 in mice; n = 5–6 per group. Data are presented as mean ± SEM. Statistical significance was determined using one-way ANOVA with Dunnett’s post-test; *, p < 0.05 compared to control, #, p < 0.05 compared to native Pn3a (WT).