. 2020 Mar 13;3(3):547–558. doi: 10.1021/acsptsci.0c00011

Table 2. PK Comparison of Taxol vs Abraxane vs Genexol-PM^a.

	C_o	C_max	T_1/2	AUC_all	AUC_inf	V_d	CL	MRT_inf	V_ss
	ng/mL	ng/mL	h	ng·h/mL	ng·h/mL	mL/kg	mL/h·kg	h	mL/kg
Taxol Total
avg	19294^b	11066^b	11	19737^b	19770^b	325^b	324^b	3^b	964^b
SD	4890	2303	2	5597	5635	66	85	1	325
Abraxane Total
avg	1726	1091	17	2291	2324	4115	2627	7	20512
SD	498	298	9	343	332	715	379	2	6780
Genexol-PM Total
avg	1413	853	15	2176	2214	4267	3060	8	16649
SD	481	264	2	896	897	1861	1083	3	5900
Taxol Unencapsulated
avg	12238^b	9283^b	12	17699^b	17735^b	469^b	362^b	3^b	980^b
SD	1765	2041	3	5014	5053	111	99	1	189
Abraxane Unencapsulated
avg	1772	1117	22	2319	2373	4063^b	2600	7	18766
SD	631	347	14	466	450	1219	457	2	6697
Genexol-PM Unencapsulated
avg	995	744	18	2035	2066	5976	3251	8	21521
SD	354	237	4	786	797	1620	1126	3	4575
Taxol Unbound
avg	446^b	239^b	16	438^b	442^b	17525^b	14523^b	4^b	52359^b
SD	183	57	6	127	132	4649	3706	2	14110
Abraxane Unbound
avg	174	117	21	283	320	36518	20872^b	8	303918
SD	38	23	9	73	123	11545	6582	3	248205
Genexol-PM Unbound
avg	145	99	19	199	202	38773	32603	8	259769
SD	34	50	5	77	78	16073	9470	2	131868

Displayed are the average animal pharmacokinetic parameters for the Taxol (generic), Abraxane, and Genexol-PM total, unencapsulated, and unbound drug profiles: concentration time zero (C₀); half-life (T_1/2); area under the time concentration curve to time infinity (AUC_inf); maximum concentration (C_max); area under the time concentration curve all time points (AUC_all); volume of distribution (V_d); clearance (CL); mean residence time (MRT_inf); volume of distribution steady state (V_ss); half-life (T_1/2).

Significantly different than other groups, p ≤ 0.05, ANOVA with Tukey’s posthoc test.

Table 2. PK Comparison of Taxol vs Abraxane vs Genexol-PMa.

Table 2. PK Comparison of Taxol vs Abraxane vs Genexol-PM^a.