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Probabilities of target attainment for plasma, cortical bone, and cancellous bone after 1-h infusions of 400 mg of ciprofloxacin q8h (top) and q12h (bottom) at steady state. The fAUC/MIC target for plasma was 40,20 and the AUC/MIC targets for cortical and cancellous bone were 86 and 135, respectively.
