Figure 2.

FPT increases social approach behavior. Shown are the number of social approaches in an open-field from paired wild-type (WT) or Fmr1 knockout (KO) mice, one treated with vehicle (Veh) and the other FPT. (a) Vehicle-treated KO mice tended to exhibit fewer social approaches than vehicle-treated WT mice. FPT significantly increased social interactions in WT mice, relative to vehicle, and increased social interactions in KO mice, normalizing social approaches to vehicle-treated WT levels. (b) Data from (a) unmasked to show social approach results of the individual pairs of mice. These data show that each FPT-treated wild-type mouse exhibited more social approaches than its vehicle-treated pair, and 7 of 9 FPT-treated Fmr1 knockout mice exhibited more social approaches than their vehicle-treated pairs.