Table 2.
Therapeutic indices and safety margins of the antidotes of some snake venoms
| Species | LT50 (hr) | LD50 (mg/kg) | ED50 (mg/kg) | LD1 (mg/kg) | ED1 (mg/kg) | ED99 (mg/kg) | T2 | MS1 (Control) |
|---|---|---|---|---|---|---|---|---|
| Crotalus durissus terrificus (Tropical rattle snake) | 0.43 | 0.13 | 4.02 | 0.026 | 0.0804 | 7.96 | 0.69 | 0.003 |
| Crotalus scutulatus scutulatus (Mojave rattle snake) | 0.52 | 0.17 | 4.40 | 0.034 | 0.088 | 8.71 | 0.85 | 0.004 |
| Crotalus horridus africaudatus (Canebrake rattle snake) | 1.61 | 0.92 | 7.72 | 0.184 | 0.1544 | 15.29 | 4.60 | 0.012 |
| Crotalus adamanteus (Eastern diamond back rattle snake) | 2.08 | 1.35 | 8.77 | 0.27 | 0.1754 | 17.36 | 6.75 | 0.016 |
| Crotalus durissus durissus (Central American rattle snake) | 2.51 | 1.79 | 9.64 | 0.358 | 0.1928 | 19.09 | 8.95 | 0.019 |
| Agkistrodon piscivorus piscivorus (Eastern cotton mouth) | 3.84 | 3.38 | 11.91 | 0.676 | 0.2382 | 23.58 | 16.90 | 0.029 |
| Croatlus viridus helleri (Southern pacific rattle snake) | 3.92 | 3.48 | 12.03 | 0.696 | 0.2406 | 23.82 | 17.40 | 0.029 |
| Crotalus molossus molossus (Northern black-tailed rattle snake) | 4.17 | 4.42 | 13.03 | 0.884 | 0.2606 | 25.80 | 22.10 | 0.034 |
| Sistrurus miliarius barbourin (Southern pygmy rattle snake) | 4.91 | 4.87 | 13.45 | 0.974 | 0.269 | 13.45 | 24.35 | 0.072 |
| Agkistrodon contortrix contortrix (Southern Copperhead) | 5.0 | 4.99 | 13.56 | 0.998 | 0.2712 | 13.56 | 24.95 | 0.073 |
| Crotalus horridus horridus (Timber rattle snake) | 5.85 | 6.32 | 14.61 | 1.264 | 0.2922 | 14.61 | 31.60 | 0.087 |
| Micrarus fulvius | 0.79 | 0.32 | 4.77 | 0.064 | 0.0954 | 9.44 | 0.007 |
Consroe et al. established baseline LD50 values for crotalid anti venin FAB prepared from sheep immune globulin (IgG)