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. 2020 Jun 16;20:245. doi: 10.1186/s12935-020-01326-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — FBXO2 is upregulated in OS samples and cell lines. a FBXO2 mRNA and b protein expression in OS and adjacent normal tissues. The quantification plot was based on scanning densitometry analysis using the Image J software (v 1.8.0). c Immunohistochemical analyses of 20 OS and adjacent normal tissues using anti-FBXO2 antibody were performed. Representative images of IHC staining were presented. The scale bar represents 50 μm. The quantitative analysis for IHC images were shown. d FBXO2 mRNA and protein e expression in four OS cell lines and normal human osteoblastic hFOB1.19 cells