Table 4.
Hazard ratio for renal events by different BP patterns by criteria A
| Unadjusted | Model 1 | Model 2 | Model 3 | Model 4 | |
|---|---|---|---|---|---|
| HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | |
| BP patterns | |||||
| NT | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) |
| WCH | 4.07 (2.32, 7.11) | 2.38 (1.34, 4.23) | 2.36 (1.29, 4.34) | 2.37 (1.29, 4.35) | 2.38 (1.30, 4.37) |
| MH | 3.98 (2.76, 5.73) | 2.13 (1.45, 3.11) | 2.25 (1.48, 3.41) | 2.23 (1.47, 3.37) | 2.20 (1.47, 3.30) |
| SH | 5.52 (3.85, 7.93) | 2.02 (1.36, 3.00) | 2.15 (1.27, 3.63) | 2.12 (1.27, 3.57) | 2.11 (1.26, 3.54) |
| Clinic SBP (per 10 mm Hg) | 1.28 (1.21, 1.35) | – | 1.01 (0.91, 1.11) | 1.01 (0.91, 1.11) | 1.00 (0.91, 1.11) |
| 24 h-SBP (per 10 mm Hg) | 1.32 (1.24, 1.39) | – | 0.97 (0.88, 1.07) | – | – |
| D-SBP (per 10 mm Hg) | 1.31 (1.23, 1.38) | – | – | 0.98 (0.89, 1.07) | – |
| N-SBP (per 10 mm Hg) | 1.30 (1.23, 1.36) | – | – | – | 0.98 (0.90, 1.07) |
| Age | 1.00 (0.99, 1.01) | 0.99 (0.97, 0.99) | 0.98 (0.97, 0.99) | 0.98 (0.97, 0.99) | 0.98 (0.97, 0.99) |
| Sex (M vs W) | 1.32 (1.04, 1.68) | 1.74 (1.25, 2.43) | 1.74 (1.25, 2.42) | 1.74 (1.25, 2.43) | 1.74 (1.25, 2.42) |
| BMI | 0.95 (0.92, 0.99) | 0.97 (0.94, 1.01) | 0.96 (0.94, 1.01) | 0.97 (0.94, 1.01) | 0.98 (0.94, 1.01) |
| Smoker | 1.26 (0.99, 1.60) | 0.87 (0.64, 1.18) | 0.87 (0.64, 1.19) | 0.87 (0.64, 1.19) | 0.87 (0.64, 1.19) |
| DM | 1.79 (1.38, 2.32) | 1.00 (0.61, 1.63) | 1.02 (0.62, 1.66) | 1.01 (0.62, 1.65) | 1.01 (0.62, 1.66) |
| CVD history | 1.34 (0.96, 1.87) | 1.25 (0.87, 1.79) | 1.25 (0.86, 1.80) | 1.25 (0.86, 1.80) | 1.25 (0.87, 1.80) |
| Anti-hypertensive treatment | 0.34 (0.23, 0.51) | 0.66 (0.44, 1.00) | 0.67 (0.44, 1.01) | 0.67 (0.44, 1.01) | 0.66 (0.44, 1.00) |
| Dyslipidemia | 0.92 (0.69, 1.24) | 0.75 (0.54, 1.02) | 0.75 (0.54, 1.03) | 0.75 (0.54, 1.03) | 0.75 (0.54, 1.03) |
| ALB | 0.96 (0.95, 0.97) | 0.96 (0.94, 0.98) | 0.96 (0.94, 0.98) | 0.96 (0.94, 0.98) | 0.96 (0.94, 0.98) |
| Anemia | 3.70 (2.83, 4.83) | 1.33 (0.98, 1.80) | 1.33 (0.98, 1.82) | 1.33 (0.98, 1.82) | 1.33 (0.98, 1.82) |
| lgUpro | 4.51 (3.51, 5.81) | 2.23 (1.62, 3.08) | 2.25 (1.63, 3.10) | 2.25 (1.63, 3.10) | 2.25 (1.63, 3.10) |
| eGFR | 0.94 (0.93, 0.95) | 0.94 (0.93, 0.95) | 0.94 (0.93, 0.95) | 0.94 (0.93, 0.95) | 0.94 (0.93, 0.95) |
| Causes of CKD | |||||
| DKD vs others | 2.77 (1.99, 3.88) | 1.73 (0.98, 3.04) | 1.73 (0.98, 3.04) | 1.73 (0.98, 3.04) | 1.74 (0.99, 3.07) |
| GN vs others | 0.95 (0.71, 1.27) | 1.49 (1.10, 2.04) | 1.48 (1.08, 2.02) | 1.48 (1.08, 2.03) | 1.48 (1.08, 2.03) |
NT normotension, WCH white-coat hypertension, MH masked hypertension, SH sustained hypertension, HR hazard ratio, CI confidence interval, BMI body-mass index, DM diabetes mellitus, CVD history history of CV disease, ALB serum albumin, eGFR estimated glomerular filtration rate, CKD chronic kidney disease, GN glomerulonephritis, DKD diabetic kidney disease
Model 1: adjusted for age, gender, smoker, BMI, DM, CVD history, anti-hypertensive treatment, Dyslipidemia, ALB, Anemia, logarithm transformed 24 h-urine protein, eGFR and causes of CKD
Model 2: model 1 + clinic systolic blood pressures and 24-h ambulatory systolic blood pressure
Model 3: model 1 + clinic systolic blood pressures and daytime systolic blood pressure
Model 4: model 1 + clinic systolic blood pressures and nighttime systolic blood pressure