Table 5.
Hazard ratio for renal events by different BP patterns by criteria B
| Unadjusted | Model 1 | Model 2 | Model 3 | Model 4 | |
|---|---|---|---|---|---|
| HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | |
| BP patterns | |||||
| NT | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) |
| WCH | 2.76 (1.55, 4.92) | 1.98 (1.10, 3.58) | 1.90 (1.04, 3.49) | 1.90 (1.04, 3.50) | 1.90 (1.04, 3.49) |
| MH | 4.29 (2.44, 7.53) | 2.24 (1.25, 3.99) | 2.23 (1.22, 4.08) | 2.22 (1.21, 4.08) | 2.21 (1.22, 3.99) |
| SH | 5.69 (3.46, 9.34) | 2.04 (1.21, 3.41) | 1.91 (1.08, 3.37) | 1.91 (1.08, 3.37) | 1.90 (1.08, 3.33) |
| Clinic SBP (per 10 mm Hg) | 1.28 (1.21, 1.35) | – | 1.03 (0.94, 1.12) | 1.02 (0.94, 1.12) | 1.02 (0.94, 1.11) |
| 24 h-SBP (per 10 mm Hg) | 1.32 (1.24, 1.39) | – | 1.00 (0.91, 1.10) | – | – |
| D-SBP (per 10 mm Hg) | 1.31 (1.23, 1.38) | – | – | 1.00 (0.92, 1.10) | – |
| N-SBP (per 10 mm Hg) | 1.30 (1.23, 1.36) | – | – | – | 1.01 (0.93, 1.10) |
| Age | 1.00 (0.99, 1.01) | 0.98 (0.97, 0.99) | 0.98 (0.97, 0.99) | 0.98 (0.97, 0.99) | 0.98 (0.97, 0.99) |
| Sex (M vs W) | 1.32 (1.04, 1.68) | 1.79 (1.29, 2.50) | 1.78 (1.28, 2.48) | 1.78 (1.28, 2.48) | 1.78 (1.28, 2.48) |
| BMI | 0.95 (0.92, 0.99) | 0.98 (0.95, 1.01) | 0.98 (0.94, 1.01) | 0.98 (0.94, 1.01) | 0.98 (0.94, 1.01) |
| Smoker | 1.26 (0.99, 1.60) | 0.88 (0.64, 1.19) | 0.88 (0.64, 1.20) | 0.88 (0.64, 1.20) | 0.88 (0.64, 1.20) |
| DM | 1.79 (1.38, 2.32) | 1.00 (0.61, 1.62) | 1.00 (0.61, 1.63) | 1.00 (0.61, 1.63) | 0.99 (0.61, 1.63) |
| CVD history | 1.34 (0.96, 1.87) | 1.27 (0.88, 1.83) | 1.28 (0.89, 1.84) | 1.28 (0.89, 1.84) | 1.28 (0.88, 1.84) |
| Anti-hypertensive treatment | 0.34 (0.23, 0.51) | 0.63 (0.42, 0.96) | 0.64 (0.42, 0.97) | 0.64 (0.42, 0.97) | 0.64 (0.42, 0.97) |
| Dyslipidemia | 0.92 (0.69, 1.24) | 0.73 (0.53, 1.00) | 0.73 (0.53, 1.00) | 0.73 (0.53, 1.00) | 0.73 (0.53, 1.00) |
| ALB | 0.96 (0.95, 0.97) | 0.96 (0.94, 0.98) | 0.96 (0.94, 0.98) | 0.96 (0.94, 0.98) | 0.96 (0.94, 0.98) |
| Anemia | 3.70 (2.83, 4.83) | 1.36 (1.00, 1.84) | 1.34 (0.99, 1.82) | 1.34 (0.99, 1.82) | 1.34 (0.99, 1.82) |
| lgUpro | 4.51 (3.51, 5.81) | 2.33 (1.69, 3.22) | 2.31 (1.67, 3.19) | 2.31 (1.67, 3.19) | 2.30 (1.66, 3.19) |
| eGFR | 0.94 (0.93, 0.95) | 0.94 (0.93, 0.95) | 0.94 (0.93, 0.95) | 0.94 (0.93, 0.95) | 0.94 (0.93, 0.95) |
| Causes of CKD | |||||
| DKD vs others | 2.77 (1.99, 3.88) | 1.73 (0.98, 3.05) | 1.73 (0.98, 3.05) | 1.73 (0.98, 3.05) | 1.73 (0.98, 3.05) |
| GN vs others | 0.95 (0.71, 1.27) | 1.44 (1.06, 1.96) | 1.48 (1.08, 2.03) | 1.48 (1.08, 2.03) | 1.48 (1.08, 2.03) |
NT normotension, WCH white-coat hypertension, MH masked hypertension, SH sustained hypertension, HR hazard ratio, CI confidence interval, BMI body-mass index, DM diabetes mellitus, CVD history history of CV disease, ALB serum albumin, eGFR estimated glomerular filtration rate, CKD chronic kidney disease, GN glomerulonephritis, DKD diabetic kidney disease
Model 1: adjusted for age, gender, smoker, BMI, DM, CVD history, anti-hypertensive treatment, Dyslipidemia, ALB, Anemia, logarithm transformed 24 h-urine protein, eGFR and causes of CKD
Model 2: model 1 + clinic systolic blood pressures and 24-h ambulatory systolic blood pressure
Model 3: model 1 + clinic systolic blood pressures and daytime systolic blood pressure
Model 4: model 1 + clinic systolic blood pressures and nighttime systolic blood pressure